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Retatrutide (development code LY3437943) is a 39-amino acid synthetic peptide developed by Eli Lilly as the first triple-receptor agonist targeting GLP-1R, GIPR, and GCGR in a single molecule

This led to the US FDA approval of Ozempic to reduce cardiovascular risk in this specific patient population in 2020 In the HARMONY Outcomes trial, patients with type 2 diabetes and cardiovascular disease who took the GLP-1 medication saw a 22% reduction in major adverse cardiovascular events compared to placebo

Meeting Highlights From the Pharmacovigilance Risk Assessment Committee (PRAC) 811 April 2024

Effect size guidelines, sample size calculations, and statistical power in gerontology